Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation

RNA Polymerase II (Pol II) and transcription factors form concentrated hubs in cells via multivalent protein-protein interactions, often mediated by proteins with intrinsically disordered regions. During Herpes Simplex Virus infection, viral replication compartments (RCs) efficiently enrich host Pol...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: McSwiggen, David Trombley, Hansen, Anders S, Teves, Sheila S, Marie-Nelly, Hervé, Hao, Yvonne, Heckert, Alec Basil, Umemoto, Kayla K, Dugast-Darzacq, Claire, Tjian, Robert, Darzacq, Xavier
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Chromosomes and Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522219/
https://ncbi.nlm.nih.gov/pubmed/31038454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47098
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