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Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II
Hyperphosphorylation of the C-terminal domain (CTD) of the RPB1 subunit of human RNA polymerase (Pol) II is essential for transcriptional elongation and mRNA processing(1–3). The CTD contains 52 heptapeptide repeats of the consensus sequence YSPTSPS. The highly repetitive nature and abundant possibl...
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| Publicat a: | Nature |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6475116/ https://ncbi.nlm.nih.gov/pubmed/29849146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0174-3 |
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