Development and Evaluation of an (18)F-Radiolabeled Monocyclam Derivative for Imaging CXCR4 Expression

[Image: see text] In humans, C–X–C chemokine receptor type 4 (CXCR4) is a protein that is encoded by the CXCR4 gene and binds the ligand CXCL12 (also known as SDF-1). The CXCR4–CXCL12 interaction in cancer elicits biological activities that result in tumor progression and has accordingly been the su...

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Detalhes bibliográficos
Publicado no:Mol Pharm
Main Authors: Brickute, Diana, Braga, Marta, Kaliszczak, Maciej A., Barnes, Chris, Lau, Doreen, Carroll, Laurence, Stevens, Elizabeth, Trousil, Sebastian, Alam, Israt S., Nguyen, Quang-Dé, Aboagye, Eric O.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522096/
https://ncbi.nlm.nih.gov/pubmed/30883140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.9b00069
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