Lysosomes support the degradation, signaling, and mitochondrial metabolism necessary for human epidermal differentiation

Keratinocytes undergo significant structural remodeling during epidermal differentiation, including a broad transformation of the proteome coupled with a reduction in total cellular biomass. This suggests that intracellular digestion of proteins and organelles is necessary for keratinocyte different...

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Publicat a:J Invest Dermatol
Autors principals: Monteleon, Christine L., Agnihotri, Tanvir, Dahal, Ankit, Liu, Mingen, Rebecca, Vito W., Beatty, Gregory L., Amavaradi, Ravi K., Ridky, Todd W.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6521870/
https://ncbi.nlm.nih.gov/pubmed/29526763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2018.02.035
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