Expression and Clinical Significance of PERK and Phosphorylated EIF2α in Pancreatic Ductal Adenocarcinoma

OBJECTIVE: Endoplasmic reticulum (ER) stress and subsequent phosphorylation of eukaryotic initiation factor 2 alpha (eIF2α) by protein kinase R-like ER kinase (PERK) plays an important role in the development and chemoresistance of pancreatic ductal adenocarcinoma (PDAC). However the expression and...

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Pubblicato in:Pancreas
Autori principali: Wang, Eric M., Akasaka, Hironari, Zhao, Jun, Varadhachary, Gauri R, Lee, Jeffrey E., Maitra, Anirban, Fleming, Jason B, Hung, Mien-Chien, Wang, Huamin, Katz, Matthew H
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6521859/
https://ncbi.nlm.nih.gov/pubmed/30747823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPA.0000000000001248
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