Reduced expression of argininosuccinate synthetase 1 has a negative prognostic impact in patients with pancreatic ductal adenocarcinoma

Argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme for arginine biosynthesis, is expressed in many types of human malignancies. Recent studies showed that ASS1 may have tumor suppressor function and that ASS1 deficiency is associated with clinical aggressiveness in nasopharyngeal carcin...

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Bibliographic Details
Published in:PLoS One
Main Authors: Liu, Qingqing, Stewart, John, Wang, Hua, Rashid, Asif, Zhao, Jun, Katz, Matthew H., Lee, Jeffrey E., Fleming, Jason B., Maitra, Anirban, Wolff, Robert A., Varadhachary, Gauri R., Krishnan, Sunil, Wang, Huamin
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302782/
https://ncbi.nlm.nih.gov/pubmed/28187218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171985
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