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MIIP inhibits the growth of prostate cancer via interaction with PP1α and negative modulation of AKT signaling
BACKGROUND: Over-activation of phosphatidylinositol 3-kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) signaling pathway is one of important mechanisms to promote castration resistant prostate cancer, the final stage of prostate cancer (PCa). Dysregulation of PP1-meditaed AKT dephosphorylation...
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| Veröffentlicht in: | Cell Commun Signal |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6521544/ https://ncbi.nlm.nih.gov/pubmed/31092266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0355-1 |
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