MIIP inhibits the growth of prostate cancer via interaction with PP1α and negative modulation of AKT signaling

Abstract Background Over-activation of phosphatidylinositol 3-kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) signaling pathway is one of important mechanisms to promote castration resistant prostate cancer, the final stage of prostate cancer (PCa). Dysregulation of PP1-meditaed AKT dephospho...

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Autori principali: Guang Yan, Yi Ru, Fengqi Yan, Xin Xiong, Wei Hu, Tao Pan, Jianming Sun, Chi Zhang, Qinhao Wang, Xia Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2019-05-01
Serie:Cell Communication and Signaling
Soggetti:
MIIP
Proliferation
Prostate cancer
PP1α
PI3K-AKT-mTOR
Accesso online:http://link.springer.com/article/10.1186/s12964-019-0355-1
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