Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Induces Intracellular Ca(2+) Release through the Two-Pore Channel TPC1 in Metastatic Colorectal Cancer Cells

Nicotinic acid adenine dinucleotide phosphate (NAADP) gates two-pore channels 1 and 2 (TPC1 and TPC2) to elicit endo-lysosomal (EL) Ca(2+) release. NAADP-induced EL Ca(2+) signals may be amplified by the endoplasmic reticulum (ER) through the Ca(2+)-induced Ca(2+) release mechanism (CICR). Herein, w...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Faris, Pawan, Pellavio, Giorgia, Ferulli, Federica, Di Nezza, Francesca, Shekha, Mudhir, Lim, Dmitry, Maestri, Marcello, Guerra, Germano, Ambrosone, Luigi, Pedrazzoli, Paolo, Laforenza, Umberto, Montagna, Daniela, Moccia, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6521149/
https://ncbi.nlm.nih.gov/pubmed/30991693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11040542
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