Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression

Type I interferons (IFN‐I) are the principal antiviral molecules of the innate immune system and can be made by most cell types, including central nervous system cells. IFN‐I has been implicated in neuroinflammation during neurodegeneration, but its mechanism of induction and its consequences remain...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Glia
Main Authors: Nazmi, Arshed, Field, Robert H., Griffin, Eadaoin W., Haugh, Orla, Hennessy, Edel, Cox, Donal, Reis, Renata, Tortorelli, Lucas, Murray, Carol L., Lopez‐Rodriguez, Ana Belen, Jin, Lei, Lavelle, Ed C., Dunne, Aisling, Cunningham, Colm
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520218/
https://ncbi.nlm.nih.gov/pubmed/30680794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.23592
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados