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Astrocytes Are Primed by Chronic Neurodegeneration to Produce Exaggerated Chemokine and Cell Infiltration Responses to Acute Stimulation with the Cytokines IL-1β and TNF-α

Microgliosis and astrogliosis are standard pathological features of neurodegenerative disease. Microglia are primed by chronic neurodegeneration such that toll-like receptor agonists, such as LPS, drive exaggerated cytokine responses on this background. However, sterile inflammatory insults are more...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Hennessy, Edel, Griffin, Éadaoin W., Cunningham, Colm
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452550/
https://ncbi.nlm.nih.gov/pubmed/26041910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2745-14.2015
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