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Multivalent Ligand Binding to Cell Membrane Antigens: Defining the Interplay of Affinity, Valency, and Expression Density

Nature uses multivalency to govern many biological processes. The development of macromolecular and cellular therapies has largely been dependent on engineering similar polyvalent interactions to enable effective targeting. Such therapeutics typically utilize high-affinity binding domains that have...

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Detalles Bibliográficos
Publicado en:J Am Chem Soc
Main Authors: Csizmar, Clifford M., Petersburg, Jacob R., Perry, Thomas J., Rozumalski, Lakmal, Hackel, Benjamin J., Wagner, Carston R.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520051/
https://ncbi.nlm.nih.gov/pubmed/30507196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b09198
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