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Substrate-engaged 26S proteasome structures reveal mechanisms for ATP-hydrolysis–driven translocation
INTRODUCTION: As the major protease in eukaryotic cells and the final component of the ubiquitin-proteasome system, the 26S proteasome is responsible for protein homeostasis and the regulation of numerous vital processes. Misfolded, damaged, or obsolete regulatory proteins are marked for degradation...
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| Publicado no: | Science |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6519459/ https://ncbi.nlm.nih.gov/pubmed/30309908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav0725 |
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