Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis

The costimulatory CD40L–CD40 dyad plays a major role in multiple sclerosis (MS). CD40 is highly expressed on MHCII(+) B cells, dendritic cells and macrophages in human MS lesions. Here we investigated the role of the CD40 downstream signaling intermediates TNF receptor‐associated factor 2 (TRAF2) an...

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Detalles Bibliográficos
Publicado en:J Pathol
Autores principales: Aarts, Suzanne ABM, Seijkens, Tom TP, Kusters, Pascal JH, van Tiel, Claudia M, Reiche, Myrthe E, den Toom, Myrthe, Beckers, Linda, van Roomen, Cindy PAA, de Winther, Menno PJ, Kooij, Gijs, Lutgens, Esther
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley & Sons, Ltd 2019
Materias:
Original Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6519352/
https://ncbi.nlm.nih.gov/pubmed/30471110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.5205
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