Localization of active endogenous and exogenous β‐glucocerebrosidase by correlative light‐electron microscopy in human fibroblasts

β‐Glucocerebrosidase (GBA) is the enzyme that degrades glucosylceramide in lysosomes. Defects in GBA that result in overall loss of enzymatic activity give rise to the lysosomal storage disorder Gaucher disease, which is characterized by the accumulation of glucosylceramide in tissue macrophages. Ga...

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Vydáno v:Traffic
Hlavní autoři: van Meel, Eline, Bos, Erik, van der Lienden, Martijn J. C., Overkleeft, Herman S., van Kasteren, Sander I., Koster, Abraham J., Aerts, Johannes M. F. G.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons A/S 2019
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6519279/
https://ncbi.nlm.nih.gov/pubmed/30895685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tra.12641
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