Localization of active endogenous and exogenous β‐glucocerebrosidase by correlative light‐electron microscopy in human fibroblasts

β‐Glucocerebrosidase (GBA) is the enzyme that degrades glucosylceramide in lysosomes. Defects in GBA that result in overall loss of enzymatic activity give rise to the lysosomal storage disorder Gaucher disease, which is characterized by the accumulation of glucosylceramide in tissue macrophages. Ga...

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Detalhes bibliográficos
Publicado no:Traffic
Main Authors: van Meel, Eline, Bos, Erik, van der Lienden, Martijn J. C., Overkleeft, Herman S., van Kasteren, Sander I., Koster, Abraham J., Aerts, Johannes M. F. G.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons A/S 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6519279/
https://ncbi.nlm.nih.gov/pubmed/30895685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tra.12641
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