Disruption of sialic acid metabolism drives tumor growth by augmenting CD8(+) T cell apoptosis

Sialylated glycan structures are known for their immunomodulatory capacities and their contribution to tumor immune evasion. However, the role of aberrant sialylation in colorectal cancer and the consequences of complete tumor desialylation on anti‐tumor immunity remain unstudied. Here, we report th...

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Vydáno v:Int J Cancer
Hlavní autoři: Cornelissen, Lenneke A.M., Blanas, Athanasios, van der Horst, Joost C., Kruijssen, Laura, Zaal, Anouk, O'Toole, Tom, Wiercx, Lieke, van Kooyk, Yvette, van Vliet, Sandra J.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Inc. 2019
Témata:
Tumor Immunology and Microenvironment
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6519079/
https://ncbi.nlm.nih.gov/pubmed/30578646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.32084
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