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Disruption of sialic acid metabolism drives tumor growth by augmenting CD8(+) T cell apoptosis

Sialylated glycan structures are known for their immunomodulatory capacities and their contribution to tumor immune evasion. However, the role of aberrant sialylation in colorectal cancer and the consequences of complete tumor desialylation on anti‐tumor immunity remain unstudied. Here, we report th...

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Detalhes bibliográficos
Publicado no:Int J Cancer
Main Authors: Cornelissen, Lenneke A.M., Blanas, Athanasios, van der Horst, Joost C., Kruijssen, Laura, Zaal, Anouk, O'Toole, Tom, Wiercx, Lieke, van Kooyk, Yvette, van Vliet, Sandra J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6519079/
https://ncbi.nlm.nih.gov/pubmed/30578646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.32084
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