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Targeting intermediary metabolism enhances the efficacy of BH3 mimetic therapy in hematologic malignancies

BH3 mimetics are novel targeted drugs with remarkable specificity, potency and enormous potential to improve cancer therapy. However, acquired resistance is an emerging problem. We report the rapid development of resistance in chronic lymphocytic leukemia cells isolated from patients exposed to incr...

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Publicat a:Haematologica
Autors principals: Al-Zebeeby, Aoula, Vogler, Meike, Milani, Mateus, Richards, Caitlin, Alotibi, Ahoud, Greaves, Georgia, Dyer, Martin J.S., Cohen, Gerald M., Varadarajan, Shankar
Format: Artigo
Idioma:Inglês
Publicat: Ferrata Storti Foundation 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6518917/
https://ncbi.nlm.nih.gov/pubmed/30467206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.204701
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