High glucose promotes pancreatic cancer cells to escape from immune surveillance via AMPK-Bmi1-GATA2-MICA/B pathway

BACKGROUND: Modulation of cell surface expression of MHC class I chain-related protein A/B (MICA/B) has been proven to be one of the mechanisms by which tumor cells escape from NK cell-mediated killing. Abnormal metabolic condition, such as high glucose, may create a cellular stress milieu to induce...

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Vydáno v:J Exp Clin Cancer Res
Hlavní autoři: Duan, Qingke, Li, Hehe, Gao, Chenggang, Zhao, Hengqiang, Wu, Shihong, Wu, Heshui, Wang, Chunyou, Shen, Qiang, Yin, Tao
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6518784/
https://ncbi.nlm.nih.gov/pubmed/31088566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1209-9
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