Preclinical validation of 3-phosphoinositide-dependent protein kinase 1 inhibition in pancreatic cancer

BACKGROUND: The very aggressive nature and low survival rate of pancreatic ductal adenocarcinoma (PDAC) dictates the necessity to find novel efficacious therapies. Recent evidence suggests that phosphoinositide 3-kinase (PI3K) and 3-phosphoinositide-dependent protein kinase 1 (PDK1) are key effector...

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Dades bibliogràfiques
Publicat a:J Exp Clin Cancer Res
Autors principals: Emmanouilidi, Aikaterini, Fyffe, Chanse A., Ferro, Riccardo, Edling, Charlotte E., Capone, Emily, Sestito, Simona, Rapposelli, Simona, Lattanzio, Rossano, Iacobelli, Stefano, Sala, Gianluca, Maffucci, Tania, Falasca, Marco
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6518649/
https://ncbi.nlm.nih.gov/pubmed/31088502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1191-2
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