Regulation of death receptor signaling by the autophagy protein TP53INP2

TP53INP2 positively regulates autophagy by binding to Atg8 proteins. Here, we uncover a novel role of TP53INP2 in death‐receptor signaling. TP53INP2 sensitizes cells to apoptosis induced by death receptor ligands. In keeping with this, TP53INP2 deficiency in cultured cells or mouse livers protects a...

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Detalles Bibliográficos
Publicado en:EMBO J
Main Authors: Ivanova, Saška, Polajnar, Mira, Narbona‐Perez, Alvaro Jesus, Hernandez‐Alvarez, Maria Isabel, Frager, Petra, Slobodnyuk, Konstantin, Plana, Natalia, Nebreda, Angel R, Palacin, Manuel, Gomis, Roger R, Behrends, Christian, Zorzano, Antonio
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2019
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6518029/
https://ncbi.nlm.nih.gov/pubmed/30979779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899300
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