Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes

A precise balance between protein degradation and synthesis is essential to preserve skeletal muscle mass. Here, we found that TP53INP2, a homolog of the Drosophila melanogaster DOR protein that regulates autophagy in cellular models, has a direct impact on skeletal muscle mass in vivo. Using differ...

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Main Authors: Sala, David, Ivanova, Saška, Plana, Natàlia, Ribas, Vicent, Duran, Jordi, Bach, Daniel, Turkseven, Saadet, Laville, Martine, Vidal, Hubert, Karczewska-Kupczewska, Monika, Kowalska, Irina, Straczkowski, Marek, Testar, Xavier, Palacín, Manuel, Sandri, Marco, Serrano, Antonio L., Zorzano, Antonio
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001546/
https://ncbi.nlm.nih.gov/pubmed/24713655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72327
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