Regulation of death receptor signaling by the autophagy protein TP53INP2

TP53INP2 positively regulates autophagy by binding to Atg8 proteins. Here, we uncover a novel role of TP53INP2 in death‐receptor signaling. TP53INP2 sensitizes cells to apoptosis induced by death receptor ligands. In keeping with this, TP53INP2 deficiency in cultured cells or mouse livers protects a...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Ivanova, Saška, Polajnar, Mira, Narbona‐Perez, Alvaro Jesus, Hernandez‐Alvarez, Maria Isabel, Frager, Petra, Slobodnyuk, Konstantin, Plana, Natalia, Nebreda, Angel R, Palacin, Manuel, Gomis, Roger R, Behrends, Christian, Zorzano, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6518029/
https://ncbi.nlm.nih.gov/pubmed/30979779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899300
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