A universal transcriptomic signature of age reveals the temporal scaling of Caenorhabditis elegans aging trajectories

We collected 60 age-dependent transcriptomes for C. elegans strains including four exceptionally long-lived mutants (mean adult lifespan extended 2.2- to 9.4-fold) and three examples of lifespan-increasing RNAi treatments. Principal Component Analysis (PCA) reveals aging as a transcriptomic drift al...

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Published in:Sci Rep
Main Authors: Tarkhov, Andrei E., Alla, Ramani, Ayyadevara, Srinivas, Pyatnitskiy, Mikhail, Menshikov, Leonid I., Shmookler Reis, Robert J., Fedichev, Peter O.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6517414/
https://ncbi.nlm.nih.gov/pubmed/31089188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43075-z
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