cisTopic: cis-Regulatory topic modelling on single-cell ATAC-seq data

We present cisTopic, a probabilistic framework to simultaneously discover co-accessible enhancers and stable cell states from sparse single-cell epigenomics data (http://github.com/aertslab/cistopic). On a compendium of single-cell ATAC-seq datasets from differentiating hematopoietic cells, brain, a...

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Publicado en:Nat Methods
Main Authors: González-Blas, Carmen Bravo, Minnoye, Liesbeth, Papasokrati, Dafni, Aibar, Sara, Hulselmans, Gert, Christiaens, Valerie, Davie, Kristofer, Wouters, Jasper, Aerts, Stein
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6517279/
https://ncbi.nlm.nih.gov/pubmed/30962623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-019-0367-1
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