Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

To discover leads for next-generation chemoprotective antimalarial drugs,we tested more than 500,000 compounds for their ability to inhibit liver-stage development of luciferase-expressing Plasmodium spp. parasites (681 compounds showed a half-maximal inhibitory concentration of less than 1micromola...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Science
Asıl Yazarlar: Antonova-Koch, Yevgeniya, Meister, Stephan, Abraham, Matthew, Luth, Madeline R., Ottilie, Sabine, Lukens, Amanda K., Sakata-Kato, Tomoyo, Vanaerschot, Manu, Owen, Edward, Jado, Juan Carlos, Maher, Steven P., Calla, Jaeson, Plouffe, David, Zhong, Yang, Chen, Kaisheng, Chaumeau, Victor, Conway, Amy J., McNamara, Case W., Ibanez, Maureen, Gagaring, Kerstin, Serrano, Fernando Neria, Eribez, Korina, Taggard, Cullin McLean, Cheung, Andrea L., Lincoln, Christie, Ambachew, Biniam, Rouillier, Melanie, Siegel, Dionicio, Nosten, François, Kyle, Dennis E., Gamo, Francisco-Javier, Zhou, Yingyao, Llinás, Manuel, Fidock, David A., Wirth, Dyann F., Burrows, Jeremy, Campo, Brice, Winzeler, Elizabeth A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Association for the Advancement of Science 2018
Konular:
Antimalarials
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516198/
https://ncbi.nlm.nih.gov/pubmed/30523084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aat9446
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller