ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice

BACKGROUND: Alzheimer’s disease (AD) is defined by amyloid beta (Aβ) plaques and neurofibrillary tangles and characterized by neurodegeneration and memory loss. The majority of AD patients also have Aβ deposition in cerebral vessels known as cerebral amyloid angiopathy (CAA), microhemorrhages, and v...

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Detalhes bibliográficos
Publicado no:Alzheimers Res Ther
Main Authors: Button, Emily B., Boyce, Guilaine K., Wilkinson, Anna, Stukas, Sophie, Hayat, Arooj, Fan, Jianjia, Wadsworth, Brennan J., Robert, Jerome, Martens, Kris M., Wellington, Cheryl L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6515644/
https://ncbi.nlm.nih.gov/pubmed/31084613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-019-0497-9
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