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Ligand Selectivity in the Recognition of Protoberberine Alkaloids by Hybrid-2 Human Telomeric G-Quadruplex: Binding Free Energy Calculation, Fluorescence Binding, and NMR Experiments

The human telomeric G-quadruplex (G4) is an attractive target for developing anticancer drugs. Natural products protoberberine alkaloids are known to bind human telomeric G4 and inhibit telomerase. Among several structurally similar protoberberine alkaloids, epiberberine (EPI) shows the greatest spe...

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Bibliografiske detaljer
Udgivet i:Molecules
Main Authors: Deng, Nanjie, Xia, Junchao, Wickstrom, Lauren, Lin, Clement, Wang, Kaibo, He, Peng, Yin, Yunting, Yang, Danzhou
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6515380/
https://ncbi.nlm.nih.gov/pubmed/31010072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24081574
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