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Resolving the Ligand Binding Specificity in c-MYC G-quadruplex DNA: Absolute Binding Free Energy Calculations and SPR Experiment

We report the absolute binding free energy calculation and surface plasmon resonance (SPR) experiment for ligand binding with the cMYC G-quadruplex DNA. The unimolecular parallel DNA G-quadruplex formed in the nuclease hypersensitivity element III1 of the c-MYC gene promoter regulates the c-MYC tran...

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Publicat a:J Phys Chem B
Autors principals: Deng, Nanjie, Wickstrom, Lauren, Cieplak, Piotr, Lin, Clement, Yang, Danzhou
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5825213/
https://ncbi.nlm.nih.gov/pubmed/29086571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.7b09406
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