FK506 Induces Ligand-Independent Activation of the Bone Morphogenetic Protein Pathway and Osteogenesis

Osteoinductive bone morphogenetic proteins (BMPs), including BMP-2, have a unique capability of mediating bone formation both in orthotopic and ectopic locations. Immunosuppresive macrolides have been shown to potentiate BMP-2 activity through FKBP12, but these have yet to translate to effective ost...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Sangadala, Sreedhara, Devereaux, Emily J., Presciutti, Steven M., Boden, Scott D., Willet, Nick J.
Format: Artigo
Language:Inglês
Published: MDPI 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6515024/
https://ncbi.nlm.nih.gov/pubmed/30999619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20081900
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