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Development and optimization of a cell-based assay for the selection of synthetic compounds that potentiate bone morphogenetic protein-2 activity

The requirement of large amounts of the recombinant human bone morphogenetic protein-2 (BMP-2) produces a huge translational barrier for its routine clinical use due to high cost. This leads to an urgent need to develop alternative methods to lower costs and/or increase efficacies for using BMP-2. I...

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Detalhes bibliográficos
Main Authors: Okada, Motohiro, Sangadala, Sreedhara, Liu, Yunshan, Yoshida, Munehito, Reddy, Boojala Vijay B., Titus, Louisa, Boden, Scott D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858640/
https://ncbi.nlm.nih.gov/pubmed/19862690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbf.1615
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