IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis

Interleukin 6 (IL-6) supports development of bone-resorbing osteoclasts by acting early in the osteoblast lineage via membrane-bound (cis) or soluble (trans) receptors. Here, we investigated how IL-6 signals and modifies gene expression in differentiated osteoblasts and osteocytes and determined whe...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: McGregor, Narelle E., Murat, Melissa, Elango, Jeevithan, Poulton, Ingrid J., Walker, Emma C., Crimeen-Irwin, Blessing, Ho, Patricia W. M., Gooi, Jonathan H., Martin, T. John, Sims, Natalie A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514630/
https://ncbi.nlm.nih.gov/pubmed/30923130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008074
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