Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes

Bone strength is determined by its dense cortical shell, generated by unknown mechanisms. Here we use the Dmp1(Cre):Socs3(f/f) mouse, with delayed cortical bone consolidation, to characterise cortical maturation and identify control signals. We show that cortical maturation requires a reduction in c...

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Publicat a:eLife
Autors principals: Walker, Emma C, Truong, Kim, McGregor, Narelle E, Poulton, Ingrid J, Isojima, Tsuyoshi, Gooi, Jonathan H, Martin, T John, Sims, Natalie A
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2020
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253175/
https://ncbi.nlm.nih.gov/pubmed/32458800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56666
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