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Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes
Bone strength is determined by its dense cortical shell, generated by unknown mechanisms. Here we use the Dmp1(Cre):Socs3(f/f) mouse, with delayed cortical bone consolidation, to characterise cortical maturation and identify control signals. We show that cortical maturation requires a reduction in c...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7253175/ https://ncbi.nlm.nih.gov/pubmed/32458800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56666 |
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