Proteolytic dynamics of human 20S thymoproteasome

An efficient immunosurveillance of CD8(+) T cells in the periphery depends on positive/negative selection of thymocytes and thus on the dynamics of antigen degradation and epitope production by thymoproteasome and immunoproteasome in the thymus. Although studies in mouse systems have shown how thymo...

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Vydáno v:J Biol Chem
Hlavní autoři: Kuckelkorn, Ulrike, Stübler, Sabine, Textoris-Taube, Kathrin, Kilian, Christiane, Niewienda, Agathe, Henklein, Petra, Janek, Katharina, Stumpf, Michael P. H., Mishto, Michele, Liepe, Juliane
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Protein Synthesis and Degradation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514615/
https://ncbi.nlm.nih.gov/pubmed/30914481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007347
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