Enhanced responsiveness of platelets to vicagrel in IL‐10‐deficient mice through STAT3‐dependent up‐regulation of the hydrolase arylacetamide deacetylase in the intestine

BACKGROUND AND PURPOSE: Vicagrel is a novel promising antiplatelet drug designed for overcoming clopidogrel resistance. There is limited evidence indicating that exogenous IL‐10 suppresses CYP3A4 activity in healthy subjects and that IL‐10 knockout (KO) mice exhibit increased clopidogrel bioactivati...

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Bibliografische gegevens
Gepubliceerd in:Br J Pharmacol
Hoofdauteurs: Jia, Yu‐Meng, Zhou, Huan, Tai, Ting, Gu, Tong‐Tong, Ji, Jin‐Zi, Mi, Qiong‐Yu, Huang, Bei‐Bei, Li, Yi‐Fei, Zhu, Ting, Xie, Hong‐Guang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2019
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Research Papers
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514289/
https://ncbi.nlm.nih.gov/pubmed/30825385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14646
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