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Arylacetamide Deacetylase Is Involved in Vicagrel Bioactivation in Humans
Vicagrel, a structural analog of clopidogrel, is now being developed as a thienopyridine antiplatelet agent in a phase II clinical trial in China. Some studies have shown that vicagrel undergoes complete first-pass metabolism in human intestine, generating the hydrolytic metabolite 2-oxo-clopidogrel...
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| Publicado no: | Front Pharmacol |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5701912/ https://ncbi.nlm.nih.gov/pubmed/29209217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00846 |
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