The δ‐opioid receptor positive allosteric modulator BMS 986187 is a G‐protein‐biased allosteric agonist

BACKGROUND AND PURPOSE: The δ‐opioid receptor is an emerging target for the management of chronic pain and depression. Biased signalling, the preferential activation of one signalling pathway over another downstream of δ‐receptors, may generate better therapeutic profiles. BMS 986187 is a positive a...

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Bibliografische gegevens
Gepubliceerd in:Br J Pharmacol
Hoofdauteurs: Stanczyk, M. Alexander, Livingston, Kathryn E., Chang, Louise, Weinberg, Zara Y., Puthenveedu, Manojkumar A., Traynor, John R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2019
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Research Papers
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514288/
https://ncbi.nlm.nih.gov/pubmed/30710458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14602
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