PARP Inhibitor PJ34 Protects Mitochondria and Induces DNA-Damage Mediated Apoptosis in Combination With Cisplatin or Temozolomide in B16F10 Melanoma Cells

PARP-1 inhibition has recently been employed in both mono- and combination therapies in various malignancies including melanoma with both promising and contradicting results reported. Although deeper understanding of the underlying molecular mechanisms may help improving clinical modalities, the com...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Cseh, Anna Maria, Fabian, Zsolt, Quintana-Cabrera, Ruben, Szabo, Aliz, Eros, Krisztian, Soriano, Maria Eugenia, Gallyas, Ferenc, Scorrano, Luca, Sumegi, Balazs
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514236/
https://ncbi.nlm.nih.gov/pubmed/31133874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.00538
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