PARP Inhibition Attenuates Acute Kidney Allograft Rejection by Suppressing Cell Death Pathways and Activating PI-3K-Akt Cascade

BACKGROUND: Novel immunosuppressive therapy facilitates long term allograft survival, but acute tubular necrosis and ischemia-reperfusion during transplantation can compromise allograft function. These processes are related to oxidative stress which activates poly- (ADP-ribose) polymerase (PARP) con...

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Detalhes bibliográficos
Main Authors: Kalmar-Nagy, Karoly, Degrell, Peter, Szabo, Aliz, Sumegi, Katalin, Wittmann, Istvan, Gallyas, Ferenc, Sumegi, Balazs
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849354/
https://ncbi.nlm.nih.gov/pubmed/24312605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081928
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