A CRM1 Inhibitor Alleviates Cardiac Hypertrophy and Increases the Nuclear Distribution of NT-PGC-1α in NRVMs

Chromosomal maintenance 1 (CRM1) inhibitors display antihypertrophic effects and control protein trafficking between the nucleus and the cytoplasm. PGC-1α (peroxisome proliferator-activated receptor gamma coactivator-1alpha) is a type of transcriptional coactivator that predominantly resides in the...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Liu, Zuheng, Tian, Haiping, Hua, Jinghai, Cai, Wanqiang, Bai, Yujia, Zhan, Qiong, Lai, Wenyan, Zeng, Qingchun, Ren, Hao, Xu, Dingli
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6513890/
https://ncbi.nlm.nih.gov/pubmed/31133853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00465
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