Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus

Pathological mechanisms underlying Down syndrome (DS)/Trisomy 21, including dysregulation of essential signalling processes remain poorly understood. Combining bioinformatics with RNA and protein analysis, we identified downregulation of the Wnt/β-catenin pathway in the hippocampus of adult DS indiv...

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Publicat a:Sci Rep
Autors principals: Granno, Simone, Nixon-Abell, Jonathon, Berwick, Daniel C., Tosh, Justin, Heaton, George, Almudimeegh, Sultan, Nagda, Zenisha, Rain, Jean-Christophe, Zanda, Manuela, Plagnol, Vincent, Tybulewicz, Victor L. J., Cleverley, Karen, Wiseman, Frances K., Fisher, Elizabeth M. C., Harvey, Kirsten
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6513850/
https://ncbi.nlm.nih.gov/pubmed/31086297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43820-4
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