ALTHEA Gold Libraries™: antibody libraries for therapeutic antibody discovery

We describe here the design, construction and validation of ALTHEA Gold Libraries™. These single-chain variable fragment (scFv), semisynthetic libraries are built on synthetic human well-known IGHV and IGKV germline genes combined with natural human complementarity-determining region (CDR)-H3/J(H) (...

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Bibliografiske detaljer
Udgivet i:MAbs
Main Authors: Valadon, Philippe, Pérez-Tapia, Sonia M., Nelson, Renae S., Guzmán-Bringas, Omar U., Arrieta-Oliva, Hugo I., Gómez-Castellano, Keyla M., Pohl, Mary Ann, Almagro, Juan C.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2019
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512909/
https://ncbi.nlm.nih.gov/pubmed/30663541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1571879
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