Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor

[Image: see text] The serine/threonine protein kinase TBK1 (Tank-binding Kinase-1) is a noncanonical member of the IkB kinase (IKK) family. This kinase regulates signaling pathways in innate immunity, oncogenesis, energy homeostasis, autophagy, and neuroinflammation. Herein, we report the discovery...

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Publicat a:ACS Med Chem Lett
Autors principals: Thomson, Douglas W., Poeckel, Daniel, Zinn, Nico, Rau, Christina, Strohmer, Katrin, Wagner, Anne J., Graves, Alan P., Perrin, Jessica, Bantscheff, Marcus, Duempelfeld, Birgit, Kasparcova, Viera, Ramanjulu, Joshi M., Pesiridis, G. Scott, Muelbaier, Marcel, Bergamini, Giovanna
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2019
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512007/
https://ncbi.nlm.nih.gov/pubmed/31097999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00027
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