A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury

BACKGROUND & AIMS: We performed genetic analyses of a multiethnic cohort of patients with idiosyncratic drug-induced liver injury (DILI) to identify variants associated with susceptibility. METHODS: We performed a genome-wide association study of 2048 individuals with DILI (cases) and 12,429 ind...

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Vydáno v:Gastroenterology
Hlavní autoři: Cirulli, Elizabeth T., Nicoletti, Paola, Abramson, Karen, Andrade, Raul J., Bjornsson, Einar S., Chalasani, Naga, Fontana, Robert J., Hallberg, Pär, Li, Yi Ju, Lucena, M Isabel, Long, Nanye, Molokhia, Mariam, Nelson, Matthew R., Odin, Joseph A., Pirmohamed, Munir, Rafnar, Thorunn, Serrano, Jose, Stefansson, Kari, Stolz, Andrew, Daly, Ann K., Aithal, Guruprasad P., Watkins, Paul B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511989/
https://ncbi.nlm.nih.gov/pubmed/30664875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2019.01.034
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