Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase

[Image: see text] Mycobacterium tuberculosis adenosine kinase (MtbAdoK) is an essential enzyme of Mtb and forms part of the purine salvage pathway within mycobacteria. Evidence suggests that the purine salvage pathway might play a crucial role in Mtb survival and persistence during its latent phase...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Crespo, Roberto A., Dang, Qun, Zhou, Nian E., Guthrie, Liam M., Snavely, Thomas C., Dong, Wen, Loesch, Kimberly A., Suzuki, Takao, You, Lanying, Wang, Wei, O’Malley, Theresa, Parish, Tanya, Olsen, David B., Sacchettini, James C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511943/
https://ncbi.nlm.nih.gov/pubmed/31002508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00020
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