Circulating heparin oligosaccharides rapidly target the hippocampus in sepsis, potentially impacting cognitive functions

Sepsis induces heparanase-mediated degradation of the endothelial glycocalyx, a heparan sulfate-enriched endovascular layer critical to vascular homeostasis, releasing highly sulfated domains of heparan sulfate into the circulation. These domains are oligosaccharides rich in heparin-like trisulfated...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Zhang, Xing, Han, Xiaorui, Xia, Ke, Xu, Yongmei, Yang, Yimu, Oshima, Kaori, Haeger, Sarah M., Perez, Mario J., McMurtry, Sarah A., Hippensteel, Joseph A., Ford, Joshay A., Herson, Paco S., Liu, Jian, Schmidt, Eric P., Linhardt, Robert J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
Teme:
Physical Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511061/
https://ncbi.nlm.nih.gov/pubmed/31010931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1902227116
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