Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance

The RAS family of proto-oncogenes are among the most commonly mutated genes in human cancers and predict poor clinical outcome. Several mechanisms underlying oncogenic RAS transformation are well documented, including constitutive signaling through the RAF-MEK-ERK proproliferative pathway as well as...

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Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Lim, Jonathan K. M., Delaidelli, Alberto, Minaker, Sean W., Zhang, Hai-Feng, Colovic, Milena, Yang, Hua, Negri, Gian Luca, von Karstedt, Silvia, Lockwood, William W., Schaffer, Paul, Leprivier, Gabriel, Sorensen, Poul H.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2019
Предметы:
PNAS Plus
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511045/
https://ncbi.nlm.nih.gov/pubmed/31000598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1821323116
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