Dual-drug loaded nanoparticles of Epigallocatechin-3-gallate (EGCG)/Ascorbic acid enhance therapeutic efficacy of EGCG in a APPswe/PS1dE9 Alzheimer's disease mice model

Epigallocatechin-3-gallate (EGCG) is a candidate for treatment of Alzheimer's disease (AD) but its inherent instability limits bioavailability and effectiveness. We found that EGCG displayed increased stability when formulated as dual-drug loaded PEGylated PLGA nanoparticles (EGCG/AA NPs). Oral...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Cano, Amanda, Ettcheto, Miren, Chang, Jui-Hsien, Barroso, Emma, Espina, Marta, Kühne, Britta A., Barenys, Marta, Auladell, Carmen, Folch, Jaume, Souto, Eliana B., Camins, Antoni, Turowski, Patric, García, Maria Luisa
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science Publishers 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6510952/
https://ncbi.nlm.nih.gov/pubmed/30876953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2019.03.010
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